Welcome To The Koldobskiy Lab at the Center for Epigenetics
Understanding how the information in the human genome is utilized is one of the central questions in modern biology. It has become clear that a critical level of gene regulation occurs through the chemical modification of both the DNA itself and the proteins that organize eukaryotic DNA into chromatin. This form of gene regulation, termed epigenetics, refers to cellular “memory” other than the DNA sequence alone, and occurs through mechanisms such as the addition of methyl groups to DNA, as a way of marking specific genes as active or silent. The Feinberg Lab at the Center for Epigenetics has brought together investigators in genetics, biochemistry, cell biology, biostatistics, epidemiology, and clinical medicine to develop new technologies to apply to both basic science and population-based epigenetic studies. The center has developed several new genomics, biostatistical, and biochemical methods and is applying them to cutting-edge studies of epigenetic mechanisms and disease research.
Welcome To The Koldobskiy Lab at the Center for Epigenetics
Understanding how the information in the human genome is utilized is one of the central questions in modern biology. It has become clear that a critical level of gene regulation occurs through the chemical modification of both the DNA itself and the proteins that organize eukaryotic DNA into chromatin. This form of gene regulation, termed epigenetics, refers to cellular “memory” other than the DNA sequence alone, and occurs through mechanisms such as the addition of methyl groups to DNA, as a way of marking specific genes as active or silent. The Feinberg Lab at the Center for Epigenetics has brought together investigators in genetics, biochemistry, cell biology, biostatistics, epidemiology, and clinical medicine to develop new technologies to apply to both basic science and population-based epigenetic studies. The center has developed several new genomics, biostatistical, and biochemical methods and is applying them to cutting-edge studies of epigenetic mechanisms and disease research.
Michael A. Koldobskiy, M.D., M.S., Ph.D.
Instructor of Oncology
EXPERTISE
Pediatric Brain Cancer, Pediatric Cancer
Dr. Koldobskiy is an Instructor of Pediatric Oncology and Pediatric Neuro-Oncology at the Sidney Kimmel Comprehensive Cancer Center. He received his B.S. and M.S. from Yale University and M.D./Ph.D. in the Medical Scientist Training Program at Johns Hopkins, conducting his thesis research with Dr. Solomon Snyder in Pharmacology and Molecular Sciences. He completed his Pediatrics residency training at Johns Hopkins and his Pediatric Hematology and Oncology fellowship training in the joint Johns Hopkins/National Institutes of Health program. He studies epigenetic variability in childhood cancer.
Education
Degrees
- MD PhD, Johns Hopkins University School of Medicine (2011)
Residencies
- Johns Hopkins University School of Medicine / Pediatrics (2014)
Fellowships
- Johns Hopkins University School of Medicine / Pediatric Oncology (2017)
- National Institutes of Health / Pediatric Oncology (2017)
Board Certifications
- American Board of Pediatrics / Pediatric Hematology-Oncology (2019)
- American Board of Pediatrics / Pediatrics (2015)
Research & Publications
Lab Website: Andrew Feinberg Laboratory